Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure
نویسندگان
چکیده
منابع مشابه
Gadolinium Chelate Contrast in Pregnancy: Fetal Biodistribution in the Nonhuman Primate
Gravid macaques (n=12) were maintained on a control diet (14% calories from fat, n=4) or a high fat diet (36% calories from fat, n = 8). On gestational day 129, the macaques were injected with ProHance gadolinium contrast for placental imaging (equivalent to the third trimester). Gadolinium dose was varied based on maternal weight, using 0.1 mmol/kg dosing. Fetuses were delivered via cesarean s...
متن کاملGadolinium chelate-associated nephrogenic systemic fibrosis.
Correspondence to: Dr Kei Pin Lin Tel: (65) 6222 3322 Fax: (65) 6326 5242 Email: binglin8@ yahoo.com.sg Nephrogenic systemic fibrosis (NSF) is a rare multisystem disease characterised by widespread tissue fibrosis. It is recognised for its epidemiological association in patients with chronic renal failure, after administration of gadolinium-chelate magnetic resonance (MR) contrast agent, partic...
متن کاملGadolinium encephalopathy after intrathecal gadolinium injection.
BACKGROUND Gadolinium-induced encephalopathy is a well documented complication due to the inadvertent entrance of a high dose of gadolinium into the intrathecal compartment. In lab animals, injecting gadolinium into the intrathecal compartment resulted in neurotoxicity and seizures. It is also well recognized that the presence of autologous blood in the intrathecal compartment can cause a broad...
متن کاملSafety Evaluation and Imaging Properties of Gadolinium-Based Nanoparticles in nonhuman primates
In this article, we report the safety evaluation of gadolinium-based nanoparticles in nonhuman primates (NHP) in the context of magnetic resonance imaging (MRI) studies in atherosclerosis bearing animals and healthy controls. In healthy NHP, the pharmacokinetics and toxicity profiles demonstrated the absence of dose, time, and sex-effects, as well as a suitable tolerance of intravenous administ...
متن کاملClinical safety and diagnostic value of the gadolinium chelate gadoterate meglumine (Gd-DOTA).
OBJECTIVE The purpose of this study was to assess the diagnostic value and safety of the contrast agent gadoterate meglumine (Gd-DOTA, DOTAREM, Guerbet, Roissy CdG Cedex, France) in the setting of a postmarketing surveillance study. MATERIALS AND METHODS Between January 2004 and October 2005, radiologists in 61 radiologic institutions were asked to document the routine use of Gd-DOTA in a que...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiology
سال: 2018
ISSN: 0033-8419,1527-1315
DOI: 10.1148/radiol.2017162534